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KMID : 0378019780210020075
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New Medical Journal
1978 Volume.21 No. 2 p.75 ~ p.80
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A Clinical Study on the Treatment of Dermatomycosis with Econazole Nitrate (Pevaryl) Cream
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Abstract
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Econazole nitrate, which is an imidazole derivatives, is a new synthetic antifungal agent. It has been found to have broad spectrum against dermatophytes, yeasts, moulds and gram positive bacteria. The clinical efficacy of topical preparations of econazole nitrate has been established in the treatment of dermatophytosis, cutaneous and vulvovaginal candidiasis and tinea versicolor. The present study was investigated to assess the clinical therapeutic effects of 1% econazole nitrate (Pevaryl) cream on various cutaneous fungal infections. The subjects were 47 out-patients with clinical signs of dermatomycosis. Of these 47 patients, 25 were excluded as they were lost to follow up and no subjects had recently received either systemic or local antifungal therapy. Diagnosis was confirmed by presence of fungal hyphae or spore on 20% KOH preparation examination and positive Dermatophyte Test Medium(DTM). For identification, fungal colony on DTM was implanted on Sabouraud´s medium and also slide culture was performed. Medication was topically applied two times daily until cure was confirmed. Cure was defined as negative for 20% KOH preparation examination and culture, and disappearance of clinical signs. Cured patients were followed for an additional 4 weeks to assess any recurrance of infection. Twenty two patients with dermatomycosis were applied 1% econazole nitrate cream on involved area and following results were obtained. 1. Eighteen patients(82%) of 22 patients could be considered as cured. 2. In all patients, isolation and identification of fungal pathogen was possible and 10 were Trichophyton mentagrophvte, 4 were Trichophyton rubrum, 1 were Epidermophyton floccosum, 4 were Candida albicans and 3 were Malassezia furfur. The cure rate of Tricophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, Candida albicans and Malassezia furfur was 90%, 75%, 100%, and 66.7% respectively. 3. Eight (44.2%) of 18 cured patients were cured at 2 weeks, 8 (44.2%) of 18 patients were cured at 3 weeks and 2(11.1%) of 18 patients were cured at 4 weeks. Average duration of treatment for cure was 2.7 weeks. 4. The patients, who considered as cured by disappearance of clinical signs and negative mycological examination, were seen regularly at one week interval for 4 weeks. But no patients had any recurrence of infection. 5. Any side effects such as irritation of skin or allergic contact dermatitis were not observed during application of drug.
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